Biological activities of leukotriene derivatives and development of leukotriene antagonist.
نویسندگان
چکیده
منابع مشابه
Synthesis of leukotriene B3 derivatives.
Leukotriene B4(LTB4), a metabolite of arachidonic acid, has been reported to have various pharmacological actions such as chemotaxis, chemokinesis, aggregation and degranulation of leukocytes in vitro.' Therefore, it is thought to be a primary mediator in inflammatory and allergic states, and inhibitors of its actions are expected to have therapeutic potential. We planned to synthesize several ...
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UNLABELLED The use of radiolabeled leukocytes is considered the gold standard for scintigraphic imaging of inflammatory bowel disease. The disadvantages of (99m)Tc-hexamethylpropyleneamine oxime (HMPAO)-leukocytes, however, encourage the search for new imaging agents with at least similar diagnostic accuracy but without the laborious preparation and subsequent risk of contamination. In this stu...
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BACKGROUND Churg-Strauss syndrome (CSS) is a rare granulomatous small vessel vasculitis that occurs against a background of longstanding asthma. Leukotriene antagonists (LTAs) are used in the management of asthma and may facilitate a reduction in steroid dosage. Reports of the development of CSS in patients with asthma following the initiation of LTA therapy suggest either a causal association ...
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The leukotrienes and tumor necrosis factor (TNF) play an important role in the pathophysiology of septic shock, in which hypotension, leukopenia, thrombocytopenia, and hemoconcentration are observed. This study was performed to examine the effects of a 5-lipoxygenase inhibitor (AA-861), a selective leukotriene receptor antagonist (ONO-1078), and a cyclooxygenase inhibitor (indomethacin) on endo...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1987
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.45.136